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Showing 1–6 of 6 results
Advanced filters: Author: "Anthony Holtmaat" Clear advanced filters

  • Whole-cell recordings in mouse somatosensory cortex in vivo show that rhythmic sensory-whisker stimulation induces long-term synaptic potentiation (LTP) in layer 2/3 (L2/3) pyramidal cells, in the absence of somatic spikes, through long-lasting NMDAR-mediated depolarizations that are generated by synaptic networks originating from the posteromedial complex of the thalamus.

    • Frédéric Gambino
    • Stéphane Pagès
    • Anthony Holtmaat
    Research
    Nature
    Volume: 515, P: 116-119

  • Do cortical neurons stably represent stimulus features in different contexts? Here, using calcium imaging, the authors show that texture selectivity of individual neurons is dynamic during reversal learning. For a subclass this is contingent on the associated reward and forecasts the onset of learning.

    • Ronan Chéreau
    • Tanika Bawa
    • Anthony Holtmaat
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The formation and elimination of axonal boutons and dendritic spines is continuously taking place in the adult mammalian brain. Holtmaat and Svoboda review this structural plasticity and its dependence on cell type, sensory experiences and learning.

    • Anthony Holtmaat
    • Karel Svoboda
    Reviews
    Nature Reviews Neuroscience
    Volume: 10, P: 647-658

  • Advanced light and electron microscopy identify a subset of cortical multipolar vasoactive intestinal peptide interneurons with high spine dynamics and characteristics that are greatly different from pyramidal neurons.

    • Christina Georgiou
    • Vassilis Kehayas
    • Anthony Holtmaat
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15

  • Functional studies of neuronal assemblies that encode memories have progressed dramatically due to recent technological advances. This review shows how a focus on assembly formation and consolidation provides a powerful conceptual framework to relate mechanistic studies of synaptic, neuronal and circuit plasticity to behaviorally relevant aspects of learning and memory.

    • Anthony Holtmaat
    • Pico Caroni
    Reviews
    Nature Neuroscience
    Volume: 19, P: 1553-1562