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Showing 1–3 of 3 results
Advanced filters: Author: "Arend Sidow" Clear advanced filters

  • Understanding the basis of phenotypic variation is one of the most challenging problems in biology. The arrival of high-throughput genomic technologies now looks set to allow an integrative systems genetic approach to dissecting the genetic component of complex traits.

    • Trudy F. C. Mackay
    • Eric A. Stone
    • Julien F. Ayroles
    Reviews
    Nature Reviews Genetics
    Volume: 10, P: 565-577

  • Genome-wide association studies are not widespread in Africa, partly because of the challenges of dealing with population structure and high genomic diversity. New approaches in statistical imputation and whole-genome sequencing are now set to exploit these features for fine mapping causal variants.

    • Yik-Ying Teo
    • Kerrin S. Small
    • Dominic P. Kwiatkowski
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 149-160

  • The recent surge in sequencing output has uncovered a wealth of genetic variation, but interpretation of these data remains a challenge. This Review discusses computational and experimental methods for estimating the deleteriousness and functional significance of genetic variants to better identify those that are potentially causal for disease.

    • Gregory M. Cooper
    • Jay Shendure
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 628-640