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Showing 1–8 of 8 results
Advanced filters: Author: "Arian Laurence" Clear advanced filters

  • Direct antagonism between interleukin1 (IL-1) and the vitamin A metabolite retinoic acid tips the balance between differentiation into the TH17 subset of helper T cells or into regulatory T cells by influencing the transcription factors STAT3 and STAT5.

    • Alejandro V Villarino
    • Arian Laurence
    News & Views
    Nature Immunology
    Volume: 16, P: 226-227

  • A new subset of interleukin 17–producing CD4+ helper T cells with diverse functions has now been identified. New work by three groups substantially broadens the understanding of these cells in both mice and humans.

    • Arian Laurence
    • John J O'Shea
    News & Views
    Nature Immunology
    Volume: 8, P: 903-905

  • Interleukin-22, a component of the immune system most studied for its role in autoimmunity, has a more beneficial side. Two studies show how this cytokine fights off microbes in the mucosa of the lung and gut (pages 275–281 and 282–289).

    • Arian Laurence
    • John J O'Shea
    • Wendy T Watford
    News & Views
    Nature Medicine
    Volume: 14, P: 247-249

  • Drugs that target protein kinases have had a major impact on the treatment of cancer and now are proving beneficial in numerous immunological diseases. This Review describes their clinical application, with a focus on Janus kinase inhibitors, and how they inform mechanisms of disease and have evolved to improve efficacy and safety.

    • Leslie Castelo-Soccio
    • Hanna Kim
    • John J. O’Shea
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 787-806

  • This Review describes how next-generation sequencing has enriched our knowledge of how STAT proteins regulate cytokine-mediated T helper cell differentiation through direct DNA binding and by affecting epigenetic modifications.

    • John J. O'Shea
    • Riitta Lahesmaa
    • Yuka Kanno
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 239-250

  • Advances in our understanding of immune cell receptors and the development of biologic agents targeting them have revolutionized the treatment of rheumatoid arthritis (RA). Now, inhibitors of kinases integral to the signalling pathways downstream of these receptors have been added to the therapeutic armamentarium. This Review discusses the signalling pathways and small-molecule inhibitors of their component kinases that have already shown, or are predicted to show, promise in the treatment of RA.

    • John J. O'Shea
    • Arian Laurence
    • Iain B. McInnes
    Reviews
    Nature Reviews Rheumatology
    Volume: 9, P: 173-182