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Showing 1–8 of 8 results
Advanced filters: Author: "Ariela Benigni" Clear advanced filters

  • This Review summarizes the roles of sirtuins in kidney development, physiological processes and the pathogenesis of acute and chronic kidney diseases. The authors also highlight the potential of sirtuins as therapeutic targets to limit human kidney disease and renal ageing.

    • Luca Perico
    • Giuseppe Remuzzi
    • Ariela Benigni
    Reviews
    Nature Reviews Nephrology
    Volume: 20, P: 313-329

  • The important roles of microRNAs (miRNAs) in kidney development, homeostasis and disease are becoming increasingly recognized. These small, non-coding RNA molecules are now understood to participate in the onset and progression of pathways involved in development of end-stage renal disease; they therefore represent potential new therapeutic targets for halting progression of chronic kidney diseases. This Review describes current research investigating the roles of miRNAs in normal kidney physiology and diseases with particular attention given to the TGF-β1 pathway and its regulation by miRNAs.

    • Piera Trionfini
    • Ariela Benigni
    • Giuseppe Remuzzi
    Reviews
    Nature Reviews Nephrology
    Volume: 11, P: 23-33

  • Podocytes have a crucial role in maintaining the glomerular filtration barrier and their loss leads to glomerular disease. This Review discusses the role of podocyte actin dynamics in health and disease as well as the potential for personalized medicine approaches that target podocyte proteins.

    • Luca Perico
    • Sara Conti
    • Giuseppe Remuzzi
    Reviews
    Nature Reviews Nephrology
    Volume: 12, P: 692-710

  • Identification of the molecular pathways involved in renal pathophysiology can yield targets for intervention and aid tailored therapy. de Borst and colleagues provide an introduction to the tools that can be used to pinpoint genes involved in renal disease, including gene expression arrays, linkage analysis, association studies and animal models. Examples of genes that have been identified using these techniques are highlighted.

    • Martin H de Borst
    • Ariela Benigni
    • Giuseppe Remuzzi
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 4, P: 265-276

  • With no specific cures for most acquired chronic kidney diseases, current efforts are focused on preventing disease progression. Here, Remuzzi and colleagues discuss examples of novel drugs and biologics that might be used to target the inflammatory and profibrotic process, and glomerular injury, highlighting results from recent clinical trials.

    • Norberto Perico
    • Ariela Benigni
    • Giuseppe Remuzzi
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 936-953