Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: "Arnaud Echard" Clear advanced filters

  • Arnaud Echard discusses two studies that uncovered a key role for the ESCRT machinery in cytokinesis.

    • Arnaud Echard
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 20, P: 663

  • Completion of cell division requires severing both the microtubules and the plasma membrane that connects daughter cells. Here, the authors show that branched actin regulates ESCRT localization to promote the microtubule cut, which happens before membrane scission.

    • Tamara Advedissian
    • Stéphane Frémont
    • Arnaud Echard
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • ESCRT filaments drive the final abscission between two daughter cells but how they physically interact with the membrane is unclear. Using proteomics, the authors show that syndecan-4/syntenin/ALIX couples the ESCRT machinery to the abscission site and thus promotes efficient abscission.

    • Cyril Addi
    • Adrien Presle
    • Arnaud Echard
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • The ESCRT (endosomal sorting complex required for transport) machinery is responsible for scission of the cytokinetic bridge that connects daughter cells at the end of mitosis. Specific endosomes are now found to mediate local bridge constriction and actin clearance in human cells, which contribute to the recruitment of ESCRT components at the abscission site.

    • Arnaud Echard
    News & Views
    Nature Cell Biology
    Volume: 14, P: 983-985

  • Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-mediated depolymerization of actin, which is required to recruit ESCRT-III and complete abscission.

    • Stéphane Frémont
    • Hussein Hammich
    • Arnaud Echard
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Establishment and maintenance of apico-basal polarity in epithelial organs needs to be tightly coupled with cell division. Here the authors show that the Rab35 GTPase tethers intracellular vesicles containing key apical determinants at the cleavage site, connecting cytokinesis to apico-basal polarity.

    • Kerstin Klinkert
    • Murielle Rocancourt
    • Arnaud Echard
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • The PtdIns(4,5)P2 5-phosphatase OCRL, mutated in Lowe syndrome, is implicated in trafficking and associates with Rab GTPases. OCRL function is now extended to cytokinesis, where it controls abscission of the intercellular bridge downstream of Rab35 through the local reduction of both PtdIns(4,5)P2 levels and actin accumulation.

    • Daphné Dambournet
    • Mickael Machicoane
    • Arnaud Echard
    Research
    Nature Cell Biology
    Volume: 13, P: 981-988