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Showing 1–6 of 6 results
Advanced filters: Author: "Arnold J Levine" Clear advanced filters

  • When p53 was first discovered, it received relatively little attention from cancer researchers. The road leading to p53's rise to fame, and the recognition ofTP53as the most frequently altered gene in human cancer, has been long and winding. This Timeline examines the rich history of this pivotal tumour suppressor.

    • Arnold J. Levine
    • Moshe Oren
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 749-758

  • The p53 tumour suppressor pathway is an attractive target for the development of anticancer therapies. This Perspective highlights recent progress with agents that modulate components of the p53 pathway — in particular, p53 itself and its negative regulator MDM2 — focusing on how studies of their genetic variations, including mutations in cancer cells and inherited polymorphisms, could help tailor the use of existing agents and aid the development of novel drugs.

    • Alexei Vazquez
    • Elisabeth E. Bond
    • Gareth L. Bond
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 979-987

  • Often called “the guardian of the genome,” p53 may also be the guardian of stable development.

    • Anna M Puzio-Kuter
    • Arnold J Levine
    News & Views
    Nature Biotechnology
    Volume: 27, P: 914-915

  • The p53 family of transcription factors have diverse roles during development and in cancer. However, there is increasing evidence that their ancestral function may have been to regulate unique aspects of maternal fertility.

    • Arnold J. Levine
    • Richard Tomasini
    • Gerry Melino
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 259-265

  • The passage of transcription factors in and out of the nucleus must be regulated for their proper function. Surprisingly, regulation of nuclear trafficking among members of the signal transducer and activator of transcription (STAT) family differs, revealing specific targets for therapeutic intervention.

    • Nancy C. Reich
    • Ling Liu
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 602-612