Cardiomyopathies and cardiac channelopathies can predispose individuals to sudden cardiac death. The genetics that underlie these phenotypes are complex and incompletely understood. In this Review, Wilde and Behr discuss the indications for genetic testing of index patients, and its use in cascade testing of family members, to guide diagnosis, management, and assessment of prognosis.
- Arthur A. M. Wilde
- Elijah R. Behr