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Showing 1–6 of 6 results
Advanced filters: Author: "Arul M. Chinnaiyan" Clear advanced filters

  • A transcriptome can be readily assembled from RNA-Seq data in the absence of a reference genome.

    • Matthew K Iyer
    • Arul M Chinnaiyan
    News & Views
    Nature Biotechnology
    Volume: 29, P: 599-600

  • Recently characterized IDH1 and IDH2 mutations in leukemia and glioblastoma have introduced a fascinating cancer-specific role for metabolic genes essential to cellular respiration. Studies also link aberrant IDH1 and IDH2 activity to an altered metabolite profile, an observation that may have broad implications for both cancer epigenetics and clinical management of disease.

    • John R Prensner
    • Arul M Chinnaiyan
    News & Views
    Nature Medicine
    Volume: 17, P: 291-293

  • Gene fusions have long been known to have an important role in leukaemias, but they have recently been identified in a majority of prostate cancers. Understanding their role in this disease could lead to better targeted therapies.

    • Chandan Kumar-Sinha
    • Scott A. Tomlins
    • Arul M. Chinnaiyan
    Reviews
    Nature Reviews Cancer
    Volume: 8, P: 497-511

  • Although cancer genome sequencing is becoming routine in cancer research, cancer transcriptome profiling through methods such as RNA sequencing (RNA-seq) provides information not only on mutations but also on their functional cellular consequences. This Review discusses how technical and analytical advances in cancer transcriptomics have provided various clinically valuable insights into gene expression signatures, driver gene prioritization, cancer microenvironments, immuno-oncology and prognostic biomarkers.

    • Marcin Cieślik
    • Arul M. Chinnaiyan
    Reviews
    Nature Reviews Genetics
    Volume: 19, P: 93-109

  • Genomic rearrangements cause human genomic disorders and are implicated in many cancers. Many rearrangements do not occur at random and this Review brings together recent findings on different influences — from nuclear organization to DNA sequence — that affect where and when rearrangements happen.

    • Ram-Shankar Mani
    • Arul M. Chinnaiyan
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 819-829