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Advanced filters: Author: "Axel Diernfellner" Clear advanced filters

  • The bicyclic disulfide–containing compound thiolutin has broad antimicrobial activity and targets the essential proteasomal deubiquitinase Rpn11 and other metalloproteases, leading to inhibition of enzymatic activity through a mechanism involving zinc chelation.

    • Linda Lauinger
    • Jing Li
    • Axel Diernfellner
    Research
    Nature Chemical Biology
    Volume: 13, P: 709-714