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Showing 1–7 of 7 results
Advanced filters: Author: "B Kim" Clear advanced filters

  • Fifty-five percent of individuals vaccinated with an attenuated Plasmodium falciparum sporozoite vaccine remained without parasitemia after controlled human malaria infection one year later; immune correlate analysis in humans and non-human primates suggest a role for liver-resident T cells.

    • Andrew S Ishizuka
    • Kirsten E Lyke
    • Robert A Seder
    Research
    Nature Medicine
    Volume: 22, P: 614-623

  • Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

    • Jon O Lundberg
    • Mark T Gladwin
    • Eddie Weitzberg
    News & Views
    Nature Chemical Biology
    Volume: 5, P: 865-869

  • Immunization with Plasmodium falciparum sporozoites under chemoprophylaxis can protect against controlled human malaria infection with the same strain for at least 10 weeks, and protection correlates with polyfunctional T-cell memory.

    • Benjamin Mordmüller
    • Güzin Surat
    • Peter G. Kremsner
    Research
    Nature
    Volume: 542, P: 445-449

  • Nitric oxide is a vital signalling molecule that controls blood flow and pressure. Unexpectedly, a redox switch in the protein haemoglobin α within endothelial cells regulates this molecule's diffusion in blood vessels. See Letter p.473

    • Mark T. Gladwin
    • Daniel B. Kim-Shapiro
    News & Views
    Nature
    Volume: 491, P: 344-345

  • Solute carrier (SLC) transporters mediate a large number of physiological processes, and the dysfunction of individual transporters has been implicated in many Mendelian diseases. In this Review, Giacomini and colleagues summarize these roles and ways in which SLC transporters can be targeted by drugs, and highlight current and investigational drugs that modulate SLC transporters.

    • Lawrence Lin
    • Sook Wah Yee
    • Kathleen M. Giacomini
    Reviews
    Nature Reviews Drug Discovery
    Volume: 14, P: 543-560