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Showing 1–15 of 15 results
Advanced filters: Author: "B. Brett Finlay" Clear advanced filters

  • Type III secretion systems (T3SSs) are protein transport nanomachines that resemble molecular syringes and are found in numerous Gram-negative bacterial species. This Review summarizes our current understanding of the structure and function of these important protein secretion systems, incorporating new advances from cryo-electron microscopy and integrative imaging studies.

    • Wanyin Deng
    • Natalie C. Marshall
    • B. Brett Finlay
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 323-337

  • EightEscherichia colipathovars have been well characterized to date. In this Review Matthew Croxen and Brett Finlay discuss recent advances in our understanding of the virulence of these pathovars that cause diseases affecting hundreds of millions of people worldwide annually.

    • Matthew A. Croxen
    • B. Brett Finlay
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 26-38

  • The use of antibiotics is making lasting alterations to the long-term relationship between a host and its microbiota. Willing, Russell and Finlay describe how these changes can result in the disruption of immune homeostasis and in increased susceptibility to disease.

    • Benjamin P. Willing
    • Shannon L. Russell
    • B. Brett Finlay
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 233-243

  • Differences in the gut microbiota can influence immunity, not just at mucosal sites but also at more distal sites. But what are the implications for immunology research?

    • Navkiran Gill
    • B. Brett Finlay
    Comments & Opinion
    Nature Reviews Immunology
    Volume: 11, P: 636-637

  • An aspirin-modulated gene expression control circuit provides a powerful method to regulate expression of bacterial genes inside an infected host. This should provide a safe and easy way to study host-pathogen interactions, and may have direct therapeutic applications.

    • Ohad Gal-Mor
    • B Brett Finlay
    News & Views
    Nature Methods
    Volume: 4, P: 893-894

  • The mammalian intestine contains a large number of commensal bacterial strains. New work suggests that antimicrobial peptides used for defense against pathogenic bacteria are also used to adjust the balance among bacterial populations and to control intestinal homeostasis.

    • Alfredo Menendez
    • Rosana B R Ferreira
    • B Brett Finlay
    News & Views
    Nature Immunology
    Volume: 11, P: 49-50

  • Salmonella intestinal pathogens employ a clever trick. They use the immune response that their host triggers to destroy them to enhance the expression of genes that mediate the pathogens' virulence.

    • Michelle M. C. Buckner
    • B. Brett Finlay
    News & Views
    Nature
    Volume: 472, P: 179-180

  • Childhood malnutrition is a global health issue influenced by poorly understood microbial interactions. A new model of co-infection in mice now sheds light on the complex interplay between pathogens, the host and the resident gut microbiota during malnutrition.

    • Kelsey E. Huus
    • B. Brett Finlay
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 695-696

  • Over the next 10 years, it will be important to shift the focus of mucosal immunology research to make further advances. Examination of the mucosal immune system as a global organ, rather than as a group of individual components, will identify and characterize relationships between mucosal sites.

    • Navkiran Gill
    • Marta Wlodarska
    • B Brett Finlay
    Comments & Opinion
    Nature Immunology
    Volume: 11, P: 558-560

  • Accumulating evidence suggests that environmental experiences during childhood can result in the development of allergies that persist into adulthood. In this Review, the authors present the evidence for specific early life exposures that may tip the balance between tolerance and allergic sensitization.

    • Lisa A. Reynolds
    • B. Brett Finlay
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 518-528

  • The mouse pathogenCitrobacter rodentium has long been used as a model for investigating the pathogenesis of the important enteric human pathogens, enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli(EPEC). In this Review, Frankel and colleagues discuss the infection cycle of this pathogen, the mucosal immune response that is elicited and the role of the gut microbiota in preventing colonization.

    • James W. Collins
    • Kristie M. Keeney
    • Gad Frankel
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 612-623