The Notch signalling network is highly conserved in Metazoa and is crucial for various cell-fate decisions. Focusing onDrosophila melanogaster, this Review summarizes and integrates various recent studies, including large-scale genetic and proteomic screens that have provided a new appreciation of the complexity of Notch signalling.
- K. G. Guruharsha
- Mark W. Kankel
- Spyros Artavanis-Tsakonas