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Showing 1–6 of 6 results
Advanced filters: Author: "Beat Fierz" Clear advanced filters

  • Centromeres are defined by the histone variant CENP-A. Using single-molecule fluorescence and cryoEM, this study shows that CENP-A and the centromeric protein CENP-B collaborate to create dynamic and open chromatin, aiding centromeric factor binding.

    • Harsh Nagpal
    • Ahmad Ali-Ahmad
    • Beat Fierz
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Microtubules carry patterns of post-translational modifications that are important for the regulation of key cellular processes. Now a semi-synthetic method facilitates the production of tubulins with defined post-translational modifications. Using these designer tubulins, polyglutamylation of α-tubulin is found to promote its detyrosination by enhancing the activity of the carboxypeptidase vasohibin/small vasohibin-binding protein.

    • Eduard Ebberink
    • Simon Fernandes
    • Charlotte Aumeier
    Research
    Nature Chemistry
    Volume: 15, P: 1179-1187

  • A full understanding of chromatin in diverse cellular processes requires the consideration of its dynamics, but most standard chromatin assays provide only a static snapshot. This Review describes various emerging methods for probing chromatin dynamics across a wide range of temporal and spatial scales, and discusses the resulting biological insights.

    • Olivier Cuvier
    • Beat Fierz
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 457-472

  • Chromatin effector proteins often employ multivalent interactions with histone post-translational modifications. Here by using chemically defined nucleosome array and single-molecule microscopy, the authors show that effector multivalency prolongs chromatin retention and accelerates the association rate.

    • Sinan Kilic
    • Andreas L. Bachmann
    • Beat Fierz
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Chromatin fibers undergo continuous structural rearrangements but their dynamic architecture is poorly understood. Here, the authors use single-molecule FRET to determine the structural states and interconversion kinetics of chromatin fibers, monitoring their effector protein-dependent dynamic motions.

    • Sinan Kilic
    • Suren Felekyan
    • Beat Fierz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14