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Showing 1–4 of 4 results
Advanced filters: Author: "Benjamin F. Cravatt" Clear advanced filters

  • This Review focuses on activity-based protein profiling, which enables the discovery of cancer-relevant enzymes and selective pharmacological probes to perturb and characterize these proteins in tumour cells. When ABPP is integrated with other large-scale profiling methods, it can provide insight into the metabolic and signalling pathways that support cancer pathogenesis and indicate new strategies for treatment.

    • Daniel K. Nomura
    • Melissa M. Dix
    • Benjamin F. Cravatt
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 630-638

  • As the field of chemical biology matures, its practitioners are tackling ever more sophisticated biological problems. Chemical approaches, both synthetic and analytical, provide researchers with powerful new technologies to perturb, dissect and even reconstruct complex biological systems. Here we discuss the special challenges and opportunities confronted at the burgeoning interface of chemical and systems biology.

    • Gabriel M Simon
    • Benjamin F Cravatt
    Comments & Opinion
    Nature Chemical Biology
    Volume: 4, P: 639-642

  • Serine hydrolases are one of the largest and most diverse enzyme classes in nature and have many crucial roles in human physiology and disease. Several serine hydrolases are targets of clinically approved drugs, but many enzymes in this family remain poorly characterized and lack selective inhibitors. Here, Bachovchin and Cravatt discuss the therapeutic potential of serine hydrolases and present novel inhibitor discovery strategies.

    • Daniel A. Bachovchin
    • Benjamin F. Cravatt
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 52-68

  • Chemical probes are critical tools for elucidating the biological functions of proteins and can lead to new medicines for treating disease. The pharmacological validation of protein function requires verification that chemical probes engage their intended targets in vivo. Here we discuss technologies, both established and emergent, for measuring target engagement in living systems and propose that determining this parameter should become standard practice for chemical probe and drug discovery programs.

    • Gabriel M Simon
    • Micah J Niphakis
    • Benjamin F Cravatt
    Comments & Opinion
    Nature Chemical Biology
    Volume: 9, P: 200-205