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Showing 1–2 of 2 results
Advanced filters: Author: "Benjamin Kwok" Clear advanced filters

  • KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of different nucleotide analogues and provide the structural basis for a coordinated chemo-mechanical kinesin translocation model.

    • Matthieu P.M.H. Benoit
    • Ana B. Asenjo
    • Hernando Sosa
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • The kinesin-13 family of microtubule (MT) depolymerases are major regulators of MT dynamics. Here the authors provide insights into the MT depolymerization mechanism by solving the crystal structure of a kinesin-13 monomer (Kif2A) in complex with two bent αβ-tubulin heterodimers.

    • Daria Trofimova
    • Mohammadjavad Paydar
    • John S. Allingham
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13