Great progress has been made in elucidating the acute inflammatory components of multiple sclerosis (MS), but the pathophysiological mechanisms of the concomitant neurodegeneration are poorly understood. Friese and colleagues review the current state of knowledge regarding the pathological mechanisms of neuroaxonal dysfunction and injury in MS, highlighting evidence that axonal and neuronal impairment are early and independent contributors to disease progression.
- Manuel A. Friese
- Benjamin Schattling
- Lars Fugger