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Showing 1–8 of 8 results
Advanced filters: Author: "Bernhard Hube" Clear advanced filters

  • Both the yeast and hyphal forms of Candida albicans enable colonization of the mammalian gut, with hyphal cells secreting the toxin candidalysin to inihibit bacteria and support fungal commensalism.

    • Shen-Huan Liang
    • Shabnam Sircaik
    • Richard J. Bennett
    Research
    Nature
    Volume: 627, P: 620-627

  • This Review discusses how organ-on-chip models can applied for infectious disease research.

    • Raquel Alonso-Roman
    • Alexander S. Mosig
    • Mark S. Gresnigt
    Reviews
    Nature Microbiology
    Volume: 9, P: 891-904

  • Dual RNA sequencing and a time course infection model of vaginal epithelial cells with four Candida pathogens reveal a homogenous protective mitochondria-associated type I interferon host response at early time points, followed by distinct species-specific pathogenicity patterns.

    • Marina Pekmezovic
    • Hrant Hovhannisyan
    • Bernhard Hube
    Research
    Nature Microbiology
    Volume: 6, P: 643-657

  • Commensal bacteria such as Lactobacillus rhamnosus can inhibit the pathogenicity of the fungus Candida albicans. Here, Alonso-Roman et al. investigate the interplay between C. albicans, L. rhamnosus and intestinal epithelial cells, showing that changes in the metabolic environment, induced by the bacteria, trigger adaptations in C. albicans that reduce fungal pathogenicity.

    • Raquel Alonso-Roman
    • Antonia Last
    • Mark S. Gresnigt
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-damaging toxin to mononuclear phagocytes is a trigger of NLRP3 inflammasome activation in these cells.

    • Lydia Kasper
    • Annika König
    • Bernhard Hube
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-20

  • Bacteria use sophisticated translocation systems to manipulate or kill host cells and competing bacteria. A new study shows that bacteria also deliver anti-fungal effectors.

    • Sascha Brunke
    • Bernhard Hube
    News & Views
    Nature Microbiology
    Volume: 3, P: 860-861

  • This study identifies a cytolytic peptide toxin in the opportunistic human fungal pathogen Candida albicans—the peptide is both a crucial virulence factor that permeabilizes the host cell plasma membrane and a key signal that triggers a host danger response pathway.

    • David L. Moyes
    • Duncan Wilson
    • Julian R. Naglik
    Research
    Nature
    Volume: 532, P: 64-68