The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue following its post-translational modification. The N-end rule pathway is emerging as a major cellular proteolytic system, and recent studies provide insights into its components, substrates and functions, as well as the structural basis of substrate recognition.
- Shashikanth M. Sriram
- Bo Yeon Kim
- Yong Tae Kwon
