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Showing 1–2 of 2 results
Advanced filters: Author: "Bradley Bernstein" Clear advanced filters

  • Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with therapeutic potential.

    • Fadi J. Najm
    • Peter DeWeirdt
    • Bradley E. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Nanopore sequencing is used to profile chromatin accessibility and DNA methylation on DNA molecules over 100 kb. Phasing analysis at the H19/IGF2 locus identifies a primate-specific enhancer driving biallelic IGF2 expression in specific cellular contexts.

    • Sofia Battaglia
    • Kevin Dong
    • Bradley E. Bernstein
    Research
    Nature Genetics
    Volume: 54, P: 1504-1513