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Showing 1–4 of 4 results
Advanced filters: Author: "Bridget K. Wagner" Clear advanced filters

  • High-throughput screening in Caenorhabditis elegans identified a compound that distinctly regulates fat storage and feeding, highlighting new players in energy homeostasis.

    • Bridget K Wagner
    News & Views
    Nature Chemical Biology
    Volume: 7, P: 194-195

  • The ability to alter cell identity with small molecules represents a powerful approach to restore biological function lost because of cellular deficiency. Developing this capability through advances in chemical biology could have an enormous impact on human health.

    • Bridget K Wagner
    Comments & Opinion
    Nature Chemical Biology
    Volume: 6, P: 877-879

  • Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

    • Stuart L Schreiber
    • Alykhan F Shamji
    • Bruce A Posner
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 904-906

  • Reduced number and function of insulin-secreting β-cells is a prominent feature of both type 1 and type 2 diabetes. Wagner and colleagues discuss strategies to promote β-cell proliferation, survival and function for the treatment of diabetes, and consider ongoing challenges to drug development efforts that are aimed at targeting this cell population.

    • Amedeo Vetere
    • Amit Choudhary
    • Bridget K. Wagner
    Reviews
    Nature Reviews Drug Discovery
    Volume: 13, P: 278-289