Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that Ca2+ is a required cofactor for Fpn transport activity.
- Chandrika N. Deshpande
- T. Alex Ruwe
- Mika Jormakka
