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Showing 1–6 of 6 results
Advanced filters: Author: "C Chan" Clear advanced filters

  • Therapeutic antibodies have already improved the lives of many people living with autoimmune diseases such as rheumatoid arthritis and Crohn's disease. But there is still room for improvement. Here, the authors review how the current therapeutic antibodies work and how they might be enhanced to increase efficacy and extend their use.

    • Andrew C. Chan
    • Paul J. Carter
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 301-316

  • A recent subanalysis of data from the PEGASUS-TIMI 54 trial indicates a favourable balance between the efficacy and safety of ticagrelor in patients with prior myocardial infarction (MI), irrespective of their renal function. These results support the long-term use of ticagrelor in patients with chronic kidney disease and prior MI.

    • Noel C. Chan
    • Jacqueline Bosch
    News & Views
    Nature Reviews Nephrology
    Volume: 12, P: 10-11

  • Mitochondria contain a genome that is inherited maternally; this complicates their segregation during cell division, oogenesis and development. Mechanisms that ensure mitochondrial integrity include fusion and fission processes, organelle transport, mitophagy and genetic selection. Defects in these processes can lead to cell and tissue pathologies.

    • Prashant Mishra
    • David C. Chan
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 634-646

  • Mitochondria constantly fuse and divide, are actively transported to specific subcellular localizations and have dynamic structures. Mitochondrial dynamics is important for the functional state of mitochondria, and defects can manifest in mammalian development, apoptosis and neurodegenerative disease.

    • Scott A. Detmer
    • David C. Chan
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 870-879

  • The development of cancer involves several epigenomic alterations, and the presence of certain alterations before the development of cancer is associated with cancer risk. In this Review, the authors describe the potential of epigenomics-based assays to predict an individual's risk of cancer, including discussions of technical, practical and societal issues regarding the implementation of such assays.

    • Martin Widschwendter
    • Allison Jones
    • Nora Pashayan
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 15, P: 292-309