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Showing 1–7 of 7 results
Advanced filters: Author: "C David Allis" Clear advanced filters

  • Four studies in this issue report new mechanisms underlying the function of the chromatin remodeling SWI/SNF complex in controlling gene expression and suppressing tumor development, providing valuable insights into the treatment of cancers harboring mutations in genes encoding SWI/SNF complex subunits.

    • Chao Lu
    • C David Allis
    News & Views
    Nature Genetics
    Volume: 49, P: 178-179

  • Histone post-translational modifications have crucial roles in genome management, in part by recruiting specific factors that alter the structural properties of chromatin. These so-called effector complexes often comprise multiple histone-binding modules that may act in concert to regulate chromatin structure and DNA-related activities.

    • Alexander J. Ruthenburg
    • Haitao Li
    • C. David Allis
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 983-994

  • Increasing evidence indicates that misregulation of histone modifications can contribute to cancer. This Review summarizes how misreading, miswriting and mis-erasing histone methylation marks are involved in tumorigenesis and progression, by deregulating gene expression and perturbing cellular identity.

    • Ping Chi
    • C. David Allis
    • Gang Greg Wang
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 457-469

  • In addition to acetylation, eight types of structurally and functionally different short-chain acylations have recently been identified as important histone Lys modifications: propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation, glutarylation, crotonylation and β-hydroxybutyrylation. These modifications are regulated by enzymatic and metabolic mechanisms and have physiological functions, which include signal-dependent gene activation and metabolic stress.

    • Benjamin R. Sabari
    • Di Zhang
    • Yingming Zhao
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 90-101

  • Over the past few decades, epigenetics has evolved from a collection of curious biological phenomena to a functionally dissected research field. In this article, the authors provide a personal perspective on the advances of research into epigenetics — from its historical origins to its modern era — with a focus on molecular breakthroughs.

    • C. David Allis
    • Thomas Jenuwein
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 487-500