Promoting the development and maintenance of regulatory responses through the promotion of regulatory T (TREG) cells represents a promising approach for the induction of transplantation tolerance. In this Review, Li and Turka provide an overview of TREG cells, focusing on the challenges, opportunities, and emerging approaches in exploiting FOXP3+ TREGcells for the induction of transplant tolerance.
- Xian Chang Li
- Laurence A. Turka