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Showing 1–4 of 4 results
Advanced filters: Author: "C. Bell" Clear advanced filters

  • The epigenome has been shown to change with age, potentially impacting on ageing-related disease. Here the authors investigate the DNA methylation state of the genomic loci of human tRNA and observe enrichment for age-related DNA hypermethylation at tRNA loci.

    • Richard J. Acton
    • Wei Yuan
    • Christopher G. Bell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Targeting by tissue-specific microRNAs enhances the efficacy and safety of tumor-killing viruses.

    • John C Bell
    • David Kirn
    News & Views
    Nature Biotechnology
    Volume: 26, P: 1346-1348

  • Oncolytic viruses were originally designed as tumour-lysing therapeutics. However, they also initiate systemic antitumour immune responses. Can these viruses be exploited to enhance antitumour immune responses, and how might they be combined with other cancer immunotherapies?

    • Brian D. Lichty
    • Caroline J. Breitbach
    • John C. Bell
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 559-567

  • Breast cancer is not a single disease, but is instead a collection of diseases that have distinct histopathological features, genetic and genomic variability, and diverse prognostic outcomes. What is the most powerful way to investigate this heterogeneous disease?

    • Tracy Vargo-Gogola
    • Jeffrey M. Rosen
    Reviews
    Nature Reviews Cancer
    Volume: 7, P: 659-672