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Showing 1–4 of 4 results
Advanced filters: Author: "C. Norman" Clear advanced filters

  • Trex1 is an exonuclease that degrades cytosolic DNA and has been associated with modulation of interferon responses in autoimmunity and viral infections. Here, the authors show that Trex1 attenuates the immunogenicity of cancer cells treated with high radiation doses by degrading cytosolic DNA and preventing the activation of interferon response.

    • Claire Vanpouille-Box
    • Amandine Alard
    • Sandra Demaria
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.

    • Elena Rainero
    • Jim C. Norman
    News & Views
    Nature Cell Biology
    Volume: 17, P: 1373-1375

  • How integrins are trafficked by endocytosis markedly affects their distribution and function. Recent studies examining the molecular mechanisms of integrin trafficking show that it affects the recycling of key signalling receptors to influence cellular processes such as cytokinesis, cell migration and tumour angiogenesis.

    • Patrick T. Caswell
    • Suryakiran Vadrevu
    • Jim C. Norman
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 10, P: 843-853

  • Open collaboration on biomedical discoveries requires a fundamental shift in the traditional roles and rewards for both investigators and participants in research.

    • Stephen H Friend
    • Thea C Norman
    Comments & Opinion
    Nature Biotechnology
    Volume: 31, P: 297-303