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Showing 1–8 of 8 results
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  • Analyses of cis-genetic regulation of the plasma proteome in European and African American populations lead to the identification of shared and unique cis-protein quantitative trait loci and models for proteome-wide association studies of complex traits.

    • Jingning Zhang
    • Diptavo Dutta
    • Nilanjan Chatterjee
    Research
    Nature Genetics
    Volume: 54, P: 593-602

  • Genome-wide association studies (GWAS) have shed light on the genetic basis of chronic kidney disease (CKD). Here, Matthias Wuttke and Anna Köttgen discuss the findings of GWAS of CKD-defining traits and of GWAS of specific CKD aetiologies and their follow-up experimental and epidemiological studies, as well as their implications for future study design.

    • Matthias Wuttke
    • Anna Köttgen
    Reviews
    Nature Reviews Nephrology
    Volume: 12, P: 549-562

  • Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

    • Dmitry Shungin
    • Thomas W. Winkler
    • Karen L Mohlke
    Research
    Nature
    Volume: 518, P: 187-196

  • A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

    • Adam E. Locke
    • Bratati Kahali
    • Elizabeth K. Speliotes
    Research
    Nature
    Volume: 518, P: 197-206

  • Daniel Chasman, Daniel Levy, Christopher Newton-Cheh, Georg Ehret and colleagues perform an association meta-analysis for blood pressure in ∼330,000 individuals and identify 31 new risk loci, implicating biological pathways related to vascular function and cardiometabolic traits. Their findings highlight potential therapeutic strategies for hypertension, emphasizing a link with cardiometabolic risk.

    • Chunyu Liu
    • Aldi T Kraja
    • Daniel I Chasman
    Research
    Nature Genetics
    Volume: 48, P: 1162-1170

  • Yukinori Okada and colleagues report a meta-analysis of genome-wide association studies for kidney function–related traits in 71,149 individuals from east Asia. They identify 17 loci newly associated with the concentrations of blood urea nitrogen, serum creatinine and uric acid, and with glomerular filtration rate (eGFRcrea), several of which are also associated with chronic kidney disease.

    • Yukinori Okada
    • Xueling Sim
    • Toshihiro Tanaka
    Research
    Nature Genetics
    Volume: 44, P: 904-909