The successful replication of mammalian DNA viruses requires that they gain control of key cellular signalling pathways, including the phosphatidylinositol 3′-kinase–Akt–mammalian target of rapamycin (PI3K–Akt–mTOR) pathway. This Review discusses the range of mechanisms that mammalian DNA viruses use to activate this pathway, as well as the multiple mechanisms these viruses have evolved to circumvent inhibitory stress signalling.
- Nicholas J. Buchkovich
- Yongjun Yu
- James C. Alwine
