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Showing 1–10 of 10 results
Advanced filters: Author: "Carl Nathan" Clear advanced filters

  • This report presents themes highlighted during the eclectic and stimulating Metchnikoff's Legacy in 2008 meeting hosted at the Institut Pasteur in April 2008 in honor of the 100th anniversary of the 1908 Nobel Prize.

    • Carl Nathan
    News & Views
    Nature Immunology
    Volume: 9, P: 695-698

  • In this Science and Society article, Carl Nathan reviews historical collaborations between industry and academic instiutions that developed antimicrobials, and discusses similar strategies that have recently emerged to tackle the crisis of antimicrobial resistance.

    • Carl Nathan
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 13, P: 651-657

  • Recent research has shed light on the complex regulation and functions of reactive oxygen species (ROS) signalling. In this Review, Nathan and Cunningham-Bussel provide an update on ROS biology, and they highlight some important roles for ROS in innate and adaptive immunity.

    • Carl Nathan
    • Amy Cunningham-Bussel
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 349-361

  • Modification of a natural product with antibiotic properties to block its efflux from Mycobacterium tuberculosis results in a new drug candidate for tuberculosis with a promising therapeutic profile in mice (pages 152–158).

    • Carl Nathan
    News & Views
    Nature Medicine
    Volume: 20, P: 121-123

  • This article aims to educate immunologists about the key role of neutrophils in the initiation of immune responses, and it describes how, in contrast to conventional wisdom, neutrophils mount responses specific to their environment, making them potential targets to treat inflammation.

    • Carl Nathan
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 173-182

  • Tagging eukaryotic proteins with ubiquitin can target them for proteasomal degradation. However, despite the presence of proteasomes in several bacterial and all archaeal species, prokaryotic homologues of ubiquitin were presumed to be absent. In this Progress article, Heran Darwin describes the characterization of a prokaryotic ubiquitin-like protein (Pup) that is covalently attached to proteins, resulting in their proteasome-mediated degradation.

    • K. Heran Darwin
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 485-491

  • Ageing is associated with impaired immune responses to pathogens and vaccines. As described in this Review, ageing results in disrupted regulation of immune cell functions and innate immune receptor signalling, and in the establishment of a persistent pro-inflammatory milieu. The authors explain how this age-associated dysregulation might contribute to chronic inflammatory diseases in the elderly.

    • Albert C. Shaw
    • Daniel R. Goldstein
    • Ruth R. Montgomery
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 875-887

  • Here, John MacMicking provides a broad overview of the recently described functional properties of interferon-inducible effector proteins that mediate cell-autonomous host defence against internalized bacteria, protozoa and viruses.

    • John D. MacMicking
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 367-382