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Showing 1–6 of 6 results
Advanced filters: Author: "Carlos D. Bustamante" Clear advanced filters

  • Medical genomics has focused almost entirely on those of European descent. Other ethnic groups must be studied to ensure that more people benefit, say Carlos D. Bustamante, Esteban González Burchard and Francisco M. De La Vega.

    • Carlos D. Bustamante
    • Francisco M. De La Vega
    • Esteban G. Burchard
    Comments & Opinion
    Nature
    Volume: 475, P: 163-165

  • Comparing levels of genetic variation between the X chromosome and autosomes can reveal the different demographic histories of males and females of a species. Taking this approach, two new studies report that the effective population sizes of men and women differ, but they disagree as to which sex outnumbered the other.

    • Carlos D Bustamante
    • Sohini Ramachandran
    News & Views
    Nature Genetics
    Volume: 41, P: 8-10

  • Both strands of a diploid genome can now be efficiently sequenced de novo, unlocking the diversity of the human gene pool.

    • Carlos D Bustamante
    • Morten Rasmussen
    News & Views
    Nature Biotechnology
    Volume: 33, P: 605-606

  • Analysis of ancient nuclear DNA, recovered from 40,000-year-old remains in the Denisova Cave, Siberia, hints at the multifaceted interaction of human populations following their migration out of Africa. See Article p.1053

    • Carlos D. Bustamante
    • Brenna M. Henn
    News & Views
    Nature
    Volume: 468, P: 1044-1045

  • A large proportion of genetic variants in the human genome have been predicted to be deleterious. This Review examines the frequency and patterns of deleterious alleles in the human genome and considers recent studies with conflicting findings on whether the mutation load, or burden of deleterious alleles, differs across populations.

    • Brenna M. Henn
    • Laura R. Botigué
    • Simon Gravel
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 333-343

  • Identifying regions of the human genome that have been subject to selection is key to understanding our evolution, and provides insights into the genetic basis of disease. However, important caveats require consideration when interpreting the results of attempts to identify selected regions.

    • Rasmus Nielsen
    • Ines Hellmann
    • Andrew G. Clark
    Reviews
    Nature Reviews Genetics
    Volume: 8, P: 857-868