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Showing 1–9 of 9 results
Advanced filters: Author: "Carol Brayne" Clear advanced filters

  • The Lancet Commission on Dementia Prevention, Intervention, and Care has evaluated current evidence on dementia management, including the measures that can be taken to reduce an individual's risk of dementia. However, further intervention trials and evaluation in real-world settings are needed to alter dementia incidence globally.

    • Louise Lafortune
    • Carol Brayne
    News & Views
    Nature Reviews Neurology
    Volume: 13, P: 579-580

  • Future dramatic rises in dementia are widely reported, assuming no change in incidence. Matthews and colleagues report that, in contrast to such statements, age-specific incidence has dropped over 20 years, with overall incidence of dementia remaining stable in a large multi-site population study from England.

    • F. E. Matthews
    • B. C. M. Stephan
    • G. Forster
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • A method for determining which patients are at a high risk of developing dementia could improve preventative care, early diagnosis, and the identification of individuals for clinical trials. The late-life dementia risk index has been developed to fulfill this need in older adults, but does the model provide sufficient accuracy and reliability in assessing such risk?

    • Blossom C. M. Stephan
    • Carol Brayne
    News & Views
    Nature Reviews Neurology
    Volume: 5, P: 417-418

  • Mild cognitive impairment is widely viewed as an early stage of dementia but, as a new study highlights, some people never progress, and might even revert to normal cognition. Poor predictive validity of prodromal conditions has clear implications for the principle of 'do no harm', as overtreatment becomes a possibility.

    • Edo Richard
    • Carol Brayne
    News & Views
    Nature Reviews Neurology
    Volume: 10, P: 130-131

  • Determining how the incidence and prevalence of dementia changes over time requires population-based studies that use consistent methods over time. In this Review, the authors discuss the results of 14 worldwide studies that have attempted this approach. The findings consistently indicate that the incidence and prevalence of dementia, at least in Western countries, is stable or declining.

    • Yu-Tzu Wu
    • Alexa S. Beiser
    • Carol Brayne
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 327-339

  • Alzheimer disease (AD) is the leading cause of dementia, and is set to rise in prevalence with the growth in the global elderly population. Here, Reitz and colleagues provide a comprehensive overview of our current understanding of AD epidemiology. The authors also examine the diagnostic criteria for this disease, and discuss the use of various biomarkers to improve the accuracy of AD detection and risk prediction.

    • Christiane Reitz
    • Carol Brayne
    • Richard Mayeux
    Reviews
    Nature Reviews Neurology
    Volume: 7, P: 137-152

  • The success of future preventative treatments for dementia might rely on early and accurate identification of individuals who have a high risk of developing this condition. Here, Stephan et al. examine models of dementia risk prediction that have been tested in population-based samples. The authors discuss the predictive utility of both mild cognitive impairment criteria, and population screening models that combine cognitive deficits with other known dementia risk factors.

    • Blossom C. M. Stephan
    • Tobias Kurth
    • Carole Dufouil
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 318-326