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Showing 1–12 of 12 results
Advanced filters: Author: "Caroline Dive" Clear advanced filters

  • Cancer of unknown primary is difficult to treat due to high heterogeneity in treatment response depending on the original site. Here, the authors use DNA methylation data to develop a machine learning classifier to predict the tissue of origin from a single blood draw, allowing potential treatment changes to improve efficacy.

    • Alicia-Marie Conway
    • Simon P. Pearce
    • Dominic G. Rothwell
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX) models reveal a mechanism of drug resistance in SCLC mediated by Notch and nitric oxide activation of soluble guanylate cyclase signalling.

    • Maximilian W. Schenk
    • Sam Humphrey
    • Kristopher K. Frese
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Small cell lung cancer (SCLC) is characterised by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. The authors show that SCLC patients have a rare CTC subset with a vasculogenic mimicry (VM) phenotype, and that VM is associated with worse overall survival, and alters tumour growth, chemotherapy delivery and efficacy.

    • Stuart C. Williamson
    • Robert L. Metcalf
    • Caroline Dive
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Advances in single-cell molecular analysis are enhancing our ability to explore the mechanisms of metastasis. In this Review, the authors describe how circulating tumour cells (CTCs), captured from a minimally invasive blood test—and readily amenable to serial sampling—have the potential to inform intratumour heterogeneity and tumour evolution.

    • Matthew G. Krebs
    • Robert L. Metcalf
    • Caroline Dive
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 11, P: 129-144

  • Dive and colleagues develop an approach for genome-wide cell-free DNA methylation profiling, which can sensitively detect small cell lung cancer in liquid biopsy of patient samples, including stage I disease and molecularly defined SCLC subtypes.

    • Francesca Chemi
    • Simon P. Pearce
    • Caroline Dive
    ResearchOpen Access
    Nature Cancer
    Volume: 3, P: 1260-1270

  • Copy-number alterations detected in circulating tumor cells at time of diagnosis predict chemosensitive versus chemorefractory responses; however, CTCs obtained after subsequent relapse bear a chemosensitive copy-number alteration profile, which suggests that different mechanisms drive initial and acquired chemoresistance.

    • Louise Carter
    • Dominic G Rothwell
    • Ged Brady
    Research
    Nature Medicine
    Volume: 23, P: 114-119

  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186