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Showing 1–3 of 3 results
Advanced filters: Author: "Caroline E Shamu" Clear advanced filters

  • Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data.

    • James Inglese
    • Caroline E Shamu
    • R Kiplin Guy
    Comments & Opinion
    Nature Chemical Biology
    Volume: 3, P: 438-441

  • Many RNA interference (RNAi) screens are now performed to functionally annotate the mammalian genome. Implementing a public repository based on common data standards is essential to realize the full value of largescale RNAi data sets.

    • Caroline E. Shamu
    • Stefan Wiemann
    • Michael Boutros
    Comments & Opinion
    Nature Cell Biology
    Volume: 14, P: 115

  • RNAi is used for genome-wide functional screens in cultured cells and animals. New experimental and bioinformatics approaches, including the combination of RNAi with genome-editing strategies, has improved the efficacy of RNAi screening and follow-up experiments, and enhanced our understanding of gene function and regulatory networks.

    • Stephanie E. Mohr
    • Jennifer A. Smith
    • Norbert Perrimon
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 591-600