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Showing 1–3 of 3 results
Advanced filters: Author: "Charles D. Surh" Clear advanced filters

  • Naive T cells differentiate into memory subsets upon exposure to their cognate foreign antigen. However, before such encounters, some naive T cells are 'imprinted' through their interactions with self targets.

    • Christopher E Martin
    • Charles D Surh
    News & Views
    Nature Immunology
    Volume: 15, P: 217-219

  • The present views of how CD4+ T cells respond to antigen are based largely on artificial systems. A highly sensitive approach that allows normal T cell responses to be monitored in physiological conditions overturns some existing ideas about the differentiation of CD4+ T cells.

    • Charles D Surh
    • Jonathan Sprent
    News & Views
    Nature Immunology
    Volume: 11, P: 47-49

  • The cellular mechanism by which the cytokine TGF-β maintains the homeostasis of mature T cells and prevents the emergence of severe lethal lymphoproliferative disease has remained obscure. It is now shown that TGF-β restrains the homeostatic T cell proliferation driven by self ligands from erupting into overt autoimmunity.

    • Charles D Surh
    • Jonathan Sprent
    News & Views
    Nature Immunology
    Volume: 13, P: 628-630