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Showing 1–3 of 3 results
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  • Mammary epithelial cell development is thought to progress from undifferentiated stem cells into at least two differentiated cell types. A new study has now characterized some of these distinct developmental stages and links them to tumor subtypes previously defined by gene expression profiling (pages 907–913).

    • Aleix Prat
    • Charles M. Perou
    News & Views
    Nature Medicine
    Volume: 15, P: 842-844

  • Gene-expression profiling has led to the development of signatures designed to predict survival and treatment response in patients with breast cancer. In this Review, Prat et al. discuss the clinical utility of gene-expression-based assays and compare them with the performance of breast cancer biomarkers that are currently used as standard of care.

    • Aleix Prat
    • Matthew J. Ellis
    • Charles M. Perou
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 9, P: 48-57

  • When normal cells are compared to cancer cells by microarray analysis, the most obvious differences occur in the expression levels of genes that control cell proliferation. Can this 'proliferation signature' be used as a biomarker for cancer research and therapy?

    • Michael L. Whitfield
    • Lacy K. George
    • Charles M. Perou
    Reviews
    Nature Reviews Cancer
    Volume: 6, P: 99-106