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Showing 1–3 of 3 results
Advanced filters: Author: "Charles M Rudin" Clear advanced filters

  • In 2016, the pace of biological insights into small-cell lung cancer (SCLC) was reflected in new treatment approaches that have suggested meaningful clinical benefit to patients. We focus on three highlights of 2016: preclinical studies defining NFIB as a putative driver of metastasis, and two clinical studies; one that assessed the efficacy of an agent targeting the Notch ligand DLL3, and the other that explored T-cell checkpoint-blockade therapies targeting PD-1 and CTLA-4.

    • Charles M. Rudin
    • John T. Poirier
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 14, P: 75-76

  • Henderson and colleagues previously highlighted the need for more-rigorous standards of preclinical experimental design and reporting metrics. They now build on their earlier work with a meta-analysis of preclinical experiments that examined the efficacy of sunitinib. Their results demonstrate how suboptimal preclinical study designs can prompt unwarranted clinical expectations.

    • Eric E. Gardner
    • Charles M. Rudin
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 13, P: 8-9

  • For three decades, the treatment of small-cell lung cancer (SCLC) has remained essentially unchanged, and patient outcomes remain dismal. In the past 5 years, however, advances in our understanding of the disease, at the molecular level, have resulted in the development of new therapeutic strategies, encompassing immunotherapies and novel molecularly targeted agents. Herein, authors review the breakthroughs that hold the promise to improve SCLC outcomes.

    • Joshua K. Sabari
    • Benjamin H. Lok
    • Charles M. Rudin
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 549-561