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Showing 1–3 of 3 results
Advanced filters: Author: "Charles Y. Lin" Clear advanced filters

  • Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.

    • Nicolas Mercado
    • Gabi Schutzius
    • Susan Kirkland
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • This study investigates the effects of MYCN on the chromatin and transcriptional landscape of neuroblastoma. The authors find that, at oncogenic levels, MYCN binds to canonical E-boxes at promoters and invades enhancers, leading to transcriptional amplification.

    • Rhamy Zeid
    • Matthew A. Lawlor
    • James E. Bradner
    Research
    Nature Genetics
    Volume: 50, P: 515-523