Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: "Cheryl H. Arrowsmith" Clear advanced filters

  • The tumor suppressor p53 protects the cell from cellular stress, and in so doing it decides between cell-cycle arrest and cell death. The high-resolution structure of four DNA binding domains of p53 in complex with DNA shows how the structural collaboration between protein and DNA may influence the biological outcomes of the tumor suppressor.

    • Seth Chitayat
    • Cheryl H Arrowsmith
    News & Views
    Nature Structural & Molecular Biology
    Volume: 17, P: 390-391

  • WD40 repeat (WDR) domain-containing proteins are involved in numerous protein complexes that have been linked to disease. Schapira and colleagues describe recent advances in targeting WDR domains with small molecules to potently inhibit protein–protein interactions, and discuss the potential for the diversity and druggability of WDR domains to open up new pathways for therapeutic intervention.

    • Matthieu Schapira
    • Mike Tyers
    • Cheryl H. Arrowsmith
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 773-786

  • Epigenetic regulation of gene expression can contribute to diseases such as cancer, inflammation and neuropsychiatric disorders. Here, the authors review the protein families that mediate epigenetic signalling through histone acetylation and methylation, and highlight progress in the pharmacological modulation of each class of proteins.

    • Cheryl H. Arrowsmith
    • Chas Bountra
    • Matthieu Schapira
    Reviews
    Nature Reviews Drug Discovery
    Volume: 11, P: 384-400