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Showing 1–2 of 2 results
Advanced filters: Author: "Chris H Polman" Clear advanced filters

  • Lesion activity detected on MRI scans has become an accepted surrogate for disease activity in relapsing–remitting multiple sclerosis (MS). Barkhof and colleagues provide key recommendations for efficient use of MRI in clinical trials for relapse-onset MS, including practical issues related to acquisition, analysis and reporting of MRI data, approaches to optimization of trial design, and safety considerations.

    • Frederik Barkhof
    • Jack H. Simon
    • Massimo Filippi
    Reviews
    Nature Reviews Neurology
    Volume: 8, P: 13-21

  • Many patients with multiple sclerosis relapse or experience continued disease progression despite disease-modifying therapies, such as interferon β. This Review explores responses to interferon β treatment in patients with multiple sclerosis, discusses early identification of nonresponders, and describes a practical approach for incorporating clinical data, biological markers and MRI measures of disease activity into the management of these patients.

    • Joep Killestein
    • Chris H. Polman
    Reviews
    Nature Reviews Neurology
    Volume: 7, P: 221-228