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Advanced filters: Author: "Chris P Ponting" Clear advanced filters

  • Methods that are based on next-generation sequencing technology are used for a range of applications from genome sequencing to transcriptomic and epigenomic studies. Here, the authors discuss the important issue of sequencing depth in the design of such experiments.

    • David Sims
    • Ian Sudbery
    • Chris P. Ponting
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 121-132

  • Little is known about the functions of long noncoding RNAs compared with the amount of accumulated knowledge concerning protein-mediated mechanisms. A report now proposes a novel RNA classification based on similar kinetics of RNA synthesis, processing and turnover, and the authors predict that RNAs within each class might share functional properties.

    • Oscar C Bedoya-Reina
    • Chris P Ponting
    News & Views
    Nature Structural & Molecular Biology
    Volume: 24, P: 7-8