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Showing 1–13 of 13 results
Advanced filters: Author: "Christer Betsholtz" Clear advanced filters

  • Single-cell transcriptomic analysis of the murine blood–brain barrier provides molecular definitions of the main vascular cell types, classifies perivascular cell types and sheds light on the organization of the arteriovenous axis.

    • Michael Vanlandewijck
    • Liqun He
    • Christer Betsholtz
    Research
    Nature
    Volume: 554, P: 475-480

  • Christer Betsholtz, Christine Klein, Maria Sobrido and colleagues report the identification of mutations in the gene encoding PDGF-B that cause idiopathic basal ganglia calcification. They also show that mice carrying hypomorphic Pdgfb alleles develop brain calcifications.

    • Annika Keller
    • Ana Westenberger
    • Joao R M Oliveira
    Research
    Nature Genetics
    Volume: 45, P: 1077-1082

  • Two aspects of the blood–brain barrier — the transport of lipids to the brain and the transport of molecules across cells lining blood vessels — have been shown to be regulated by the same protein, Mfsd2a. See Letters p.503 & p.507

    • Christer Betsholtz
    News & Views
    Nature
    Volume: 509, P: 432-433

  • The blood–brain barrier (BBB) is made up of vascular endothelial cells and was thought to have formed postnatally from astrocytes. Two independent studies demonstrate that this barrier forms during embryogenesis, with pericyte/endothelial cell interactions being critical to regulate the BBB during development. A better understanding of the relationship among pericytes, neuroendothelial cells and astrocytes in BBB function will contribute to our understanding of BBB breakdown during central nervous system injury and disease.

    • Annika Armulik
    • Guillem Genové
    • Christer Betsholtz
    Research
    Nature
    Volume: 468, P: 557-561

  • How the human brain rapidly builds up its lipid content during brain growth and maintains its lipids in adulthood has remained elusive. Two new studies show that inactivating mutations in MFSD2A, known to be expressed specifically at the blood-brain barrier, lead to microcephaly, thereby offering a simple and surprising solution to an old enigma.

    • Christer Betsholtz
    News & Views
    Nature Genetics
    Volume: 47, P: 699-701

  • The formation of blood vessels requires rapid proliferation of endothelial cells. The transcription factors FOXO1 and MYC have been found to regulate the metabolism and proliferation of vascular endothelial cells. See Letter p.216

    • Christer Betsholtz
    News & Views
    Nature
    Volume: 529, P: 160-161

  • To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.

    • Lars Muhl
    • Guillem Genové
    • Christer Betsholtz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes, ranging from nutrient uptake to intracellular signal transduction. New work reinforces the importance of endocytosis for VEGF receptor signalling and angiogenesis in the developing eye, and describes a mechanism for its differential regulation in angiogenic versus quiescent endothelial cells.

    • Konstantin Gaengel
    • Christer Betsholtz
    News & Views
    Nature Cell Biology
    Volume: 15, P: 233-235

  • In this review, the authors look at how recent progress in single-cell transcriptomics complement and enrich the classical, largely morphological, portraits of fibroblasts. The detailed molecular information now available provides new insights into fibroblast identity, heterogeneity and function.

    • Urban Lendahl
    • Lars Muhl
    • Christer Betsholtz
    ReviewsOpen Access
    Nature Communications
    Volume: 13, P: 1-14