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Showing 1–3 of 3 results
Advanced filters: Author: "Christian Freund" Clear advanced filters

  • By using a combined computational and experimental approach, peptide exchange of 12 abundant MHC-II allotypes is shown to maintain responsiveness to HLA-DM catalysis. HLA-DM susceptibility is postulated to contribute to disease association.

    • Esam T. Abualrous
    • Sebastian Stolzenberg
    • Christian Freund
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 1196-1204

  • Tapasin is part of the peptide loading complex necessary for presenting antigenic peptides on MHC-I for the induction of adaptive immunity. Here the authors show that tapasin interacts with MHC-I in both conserved and allele-specific regions to promote antigen presentation, with tapasin L18 and K16 residues both implicated in this molecular interaction.

    • Huan Lan
    • Esam T. Abualrous
    • Christian Freund
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13