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Showing 1–3 of 3 results
Advanced filters: Author: "Christian Stockmann" Clear advanced filters

  • During wound healing and infection in the skin there is a hypoxic environment involving HIF-1α and NK cells. Here the authors show that NK cells through HIF-1α provide a cross-regulatory balance to provide an adequate antimicrobial defence that can inhibit subsequent wound healing.

    • Michal Sobecki
    • Ewelina Krzywinska
    • Christian Stockmann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Chemerin is an adipokine often downregulated in tumours. Here the authors show that chemotherapy induces chemerin production by endothelial cells, leading to cachexia, and that VEGF ablation in myeloid cells prevents cachexia in a chemerin-dependent manner, and improves chemotherapeutic effects.

    • Ralph Klose
    • Ewelina Krzywinska
    • Christian Stockmann
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Tumour hypoxia influences both the immune responses and angiogenesis. Here, the authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic soluble VEGFR-1, thus resulting in non-functional angiogenesis.

    • Ewelina Krzywinska
    • Chahrazade Kantari-Mimoun
    • Christian Stockmann
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13