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Showing 1–5 of 5 results
Advanced filters: Author: "Christian Trautwein" Clear advanced filters

  • Hepcidin is the iron-regulatory hormone that links innate immunity and iron metabolism. Normally, a regulatory feedback loop with circulatory iron controls hepatic hepcidin production. Inflammatory stimuli upregulate hepcidin production, which can lead to anemia. Anemia downregulates hepcidin production. Human disorders associated with inappropriate hepcidin levels include anemia of inflammation and hereditary hemochromatosis.

    • Antonello Pietrangelo
    • Christian Trautwein
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 1, P: 39-45

  • This Case Study describes a 24-year-old white male with Crohn's disease that was in remission who presented with cholestasis and hyperbilirubinemia. The patient had normal alanine aminotrasferase and γ-globulin levels, and the results of serological tests for an infectious cause of hepatopathia were negative. The patient was diagnosed with autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome on the background of primary sclerosing cholangitis.

    • Leif E Sander
    • Alexander Koch
    • Andreas Geier
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 4, P: 635-640

  • Chemokines regulate the migration of immune cells into the liver in response to acute and chronic injuries and also have roles in stellate cell activation, hepatocyte proliferation and angiogenesis. In this Review, the authors describe experimental liver disease models in which chemokines and chemokine receptors have been studied, and highlight agents that are currently under clinical investigation for use in human diseases.

    • Hacer Sahin
    • Christian Trautwein
    • Hermann E. Wasmuth
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 7, P: 682-690

  • The liver regulates immune defence during sepsis, but is also a target for sepsis-related injury. Liver dysfunction can affect the prognosis of sepsis, particularly in patients with cirrhosis. In this Review, the importance of the liver in sepsis, the factors contributing to sepsis in patients with liver cirrhosis and new therapeutic strategies are discussed.

    • Pavel Strnad
    • Frank Tacke
    • Christian Trautwein
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 14, P: 55-66

  • Proteins regulating cell cycle progression are involved in the formation of most cancer types. This Review discusses the role of cell cycle proteins in cancer, the rationale for targeting them in cancer treatment, results of clinical trials, as well as future therapeutic potential of various cell cycle inhibitors.

    • Tobias Otto
    • Piotr Sicinski
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 93-115