Mupirocin is a polyketide antibiotic produced byPseudomonas fluorescens that is used to control the carriage of methicillin-resistant Staphylococcus aureus. Here, Thomas and colleagues describe the mechanisms underlying the mode of action and biosynthesis of mupirocin and discuss how this understanding could lead to the development of novel antibiotics.
- Christopher M. Thomas
- Joanne Hothersall
- Thomas J. Simpson
