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Showing 1–2 of 2 results
Advanced filters: Author: "Christof Fellmann" Clear advanced filters
  • The use of CRISPR–Cas technology for gene editing has rapidly become widespread. Here, Corn and colleagues discuss the applications of this revolutionary tool in drug discovery and development, describing how it could make substantial contributions to target identification and validation, animal models and cell-based therapies.

    • Christof Fellmann
    • Benjamin G. Gowen
    • Jacob E. Corn
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 89-100
  • Stable RNA interference by shRNA provides a means to study multiple facets of gene function. Fellman and Lowe explore the rules of implementation of this silencing method in the vertebrate system for achieving maximal knockdown with minimal off-target effects.

    • Christof Fellmann
    • Scott W. Lowe
    Reviews
    Nature Cell Biology
    Volume: 16, P: 10-18