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Showing 1–4 of 4 results
Advanced filters: Author: "Christopher Haiman" Clear advanced filters

  • Christopher Haiman, Bogdan Pasaniuc, David Reich and colleagues report a major role for low-frequency variation in the risk for prostate cancer. They show that alleles with >1% minor allele frequency contribute an order of magnitude more to risk for prostate cancer than these alleles do to overall genetic variation.

    • Nicholas Mancuso
    • Nadin Rohland
    • David Reich
    Research
    Nature Genetics
    Volume: 48, P: 30-35

  • Chromosome 8q24 is known to be a major susceptibility region for prostate cancer risk. Here the authors analyze genetic data across the 8q24 region from 71,535 prostate cancer patients identifying 12 risk loci, three previously unreported, highlighting the contribution of germline variation at this locus.

    • Marco Matejcic
    • Edward J. Saunders
    • Christopher A. Haiman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • Genome-wide association studies (GWAS) have revealed gene variants associated with breast cancer, but their association with breast cancer development in Latinas is not clear. Here, the authors carry out a GWAS of breast cancer in Latinas and identify a significant protective variant of Indigenous American origin in the 6q25 region.

    • Laura Fejerman
    • Nasim Ahmadiyeh
    • Elad Ziv
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8