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Showing 1–8 of 8 results
Advanced filters: Author: "Christopher K. Glass" Clear advanced filters

  • A package of papers investigates the functional regulatory elements in genomes that have been obtained from human tissue samples and cell lines. The implications of the project are presented here from three viewpoints. See Articles p.317, p.331, p.337 & p.344 and Letters p.350, p.355, p.360 & p.365

    • Casey E. Romanoski
    • Christopher K. Glass
    • Genevieve Almouzni
    News & Views
    Nature
    Volume: 518, P: 314-316

  • The brain’s resident immune cells retain a long-lasting memory of peripheral inflammation. This memory can influence the response to stroke and the progression of Alzheimer’s disease in mouse models.

    • Alexi Nott
    • Christopher K. Glass
    News & Views
    Nature
    Volume: 556, P: 312-313

  • The oxysterol-dependent gene transcription factor LXRβ restricts premature expansion of T cells by limiting cellular cholesterol levels. This pathway might be a pharmacological target for regulating immune responses.

    • Christopher K. Glass
    • Kaoru Saijo
    News & Views
    Nature
    Volume: 455, P: 40-41

  • This Review article describes how a subset of nuclear receptors can antagonize pro-inflammatory gene expression, through transrepression mechanisms in macrophages and microglia, and regulate the differentiation and activation of inflammatory helper T cells, particularly T helper 17 cells.

    • Christopher K. Glass
    • Kaoru Saijo
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 365-376

  • This Review focuses on the regulation of inflammation by peroxisome-proliferator-activated receptors (PPARs) and liver X receptors (LXRs). These nuclear receptors work in combination with the glucocorticoid receptor (another member of the nuclear-receptor superfamily) to coordinate the inflammatory response.

    • Christopher K. Glass
    • Sumito Ogawa
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 44-55

  • Many gene expression patterns are dictated by enhancers. Mammalian genomes contain millions of potential enhancers, but only a small subset of them is active in any cell type. Emerging data uncover how cell type-specific enhancer function is established, including the involvement of higher-order genomic organization in the process.

    • Sven Heinz
    • Casey E. Romanoski
    • Christopher K. Glass
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 144-154

  • The classical model of gene activation by a unidirectional switch from co-repressor binding to co-activator binding is changing. This Review discusses emerging themes in the interplay among co-repressor complexes, enzymatic functions and chromatin modifications in controlling gene repression.

    • Valentina Perissi
    • Kristen Jepsen
    • Michael G. Rosenfeld
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 109-123

  • Microglia are brain-resident macrophages with a distinct origin. This Review discusses the development and function of these cells, and describes the association between the different microglial cell phenotypes and disease.

    • Kaoru Saijo
    • Christopher K. Glass
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 775-787