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Advanced filters: Author: "Christopher L. Corless" Clear advanced filters

  • In certain types of gastrointestinal cell, mutations in the protein KIT give rise to gastrointestinal stromal tumours. Why are other cell types that express KIT not affected? The answer lies with a second protein. See Letter p.849

    • Michael C. Heinrich
    • Christopher L . Corless
    News & Views
    Nature
    Volume: 467, P: 796-797

  • Although gastrointestinal stromal tumours (GISTs) are genetically heterogeneous, the identification of receptor tyrosine kinase mutations has led to improved treatments using targeted therapy. This Review discusses how the underlying genetics influences GIST disease progression and therapeutic responses, new insights into the cellular origins of GISTs and strategies for overcoming therapeutic resistance.

    • Christopher L. Corless
    • Christine M. Barnett
    • Michael C. Heinrich
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 865-878