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Showing 1–5 of 5 results
Advanced filters: Author: "Cisca Wijmenga" Clear advanced filters
  • Cisca Wijmenga reflects on a seminal publication by Houwen et al. that set the stage for genome-wide association studies and inspired her to dedicate her lab to complex trait genetics.

    • Cisca Wijmenga
    Research Highlights
    Nature Reviews Genetics
    Volume: 22, P: 480-481
  • Recent genome-wide association studies have provided evidence that some genetic loci are associated with disease susceptibility for several different immune-related disorders. Analysis of shared genetics can highlight shared pathogenic pathways that could become the focus for therapeutic intervention.

    • Alexandra Zhernakova
    • Cleo C. van Diemen
    • Cisca Wijmenga
    Reviews
    Nature Reviews Genetics
    Volume: 10, P: 43-55
  • Obesity genetics is making progress, as evidenced by the recent discovery of 15 new loci associated with body mass index. The function of the likely candidate genes in associated regions suggests a key role for the hypothalamus in the genetics of weight control.

    • Marten Hofker
    • Cisca Wijmenga
    News & Views
    Nature Genetics
    Volume: 41, P: 139-140
  • Many autoimmune diseases share a large proportion of their genetic background with other autoimmune diseases, which could result in common drug targets for several diseases. This Review focuses on the latest insights into the genetic factors that contribute to a range of autoimmune diseases.

    • Alexandra Zhernakova
    • Sebo Withoff
    • Cisca Wijmenga
    Reviews
    Nature Reviews Endocrinology
    Volume: 9, P: 646-659
  • Many autoimmune diseases are known to occur alongside coeliac disease and, in some instances, patients see improvements in both if coeliac disease is diagnosed and treated. Shared genetic traits have been identified between coeliac disease and many of these forms of autoimmunity. In this Review, an overview is presented of the genetic and immunological features of coeliac disease, its overlap with other autoimmune diseases and implications for screening strategies.

    • Knut E. A. Lundin
    • Cisca Wijmenga
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 507-515